Antiwrinkle injection ( Xeomin)

WHAT YOU NEED TO KNOW ABOUT RESISTANCE TO ANTI-WRINKLE INJECTION TREATMENTS

DID YOU KNOW THAT THERE ARE 3 ANTI-WRINKLE INJECTION TREATMENTS REGISTERED IN AUSTRALIA?

They all contain the same active ingredient (botulinum neurotoxin) however they are produced in different ways which influences the purity of the product. Some products contain unnecessary proteins, which do not help the active ingredient work in the body.

 

WHY DOES PURITY MATTER?

Anti-wrinkle treatments which contain unnecessary proteins may cause resistance to treatments.

Resistance occurs when the body produces antibodies against the treatment, which can mean that the product doesn’t last as long as it used to, or doesn’t work as well as it used to. Receiving higher doses over time may also indicate that you are developing resistance to the treatment.

It’s important to note, that botulinum neurotoxin is also one of the primary treatments used for some serious medical conditions, such as muscle spasm or tightness, following from a stroke, muscular conditions causing contractions of the neck muscles, chronic migraine, overactive bladder and other conditions. Therefore, becoming resistant to Anti-wrinkle injections may affect how well these treatment options will work for you, if you need them at any point in your life.

 

HOW COMMON IS RESISTANCE?

There is data suggesting resistance is emerging. Available data suggests resistance to botulinum toxin may start to emerge after 2 years of being on treatment. The data we have for anti-wrinkle treatment however, only studied patients for up to one year, therefore it did not follow patients for long enough to get an accurate picture of the long term rates of resistance.

However, recent studies looking at Botulinum toxin used for medical conditions, show resistance levels at up to 13%.

 

3 EASY WAYS TO KNOW IF RESISTANCE COULD BE AFFECTING YOU: 

  • Your treatment is not lasting as long as it used to
  • Your Healthcare practitioner has to increase dosage over time
  • Intervals between treatments shortened over time

 

WHAT CAN YOU DO TO MINIMISE THE RISK OF DEVELOPING RESISTANCE?

You should always seek advice from a reputable healthcare professional regarding your individual circumstances to see if treatment is suitable for you.

You may wish to ask the following questions to your doctor:

  • Which product are they recommending?
  • What are the benefits and risks of the treatment?
  • What are the options to minimise the risk of resistance?

XEOMIN® (incobotulinumtoxinA) IMPORTANT CONSUMER SAFETY INFORMATION

Read the Medication Guide before you start receiving XEOMIN® (Zeo-min) and each time XEOMIN is given to you as there may be new information. The risk information provided here is not comprehensive. To learn more:

  • Talk to your health care provider or pharmacist
  • Visit www.xeomin.com to obtain the FDA-approved product labeling

Uses

XEOMIN is a prescription medicine used in adults:

  • that is injected into glands that make saliva and is used to treat long-lasting (chronic) drooling (sialorrhea).
  • that is injected into muscles and used to:
    • treat increased muscle stiffness in the arm because of upper limb spasticity.
    • treat the abnormal head position and neck pain with cervical dystonia (CD).
    • treat abnormal spasm of the eyelids (blepharospasm) in adults.

It is not known if XEOMIN is safe and effective in children under 18 years of age.

Warnings

XEOMIN may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems anytime (hours to weeks) after treatment with XEOMIN:

  • Problems with swallowing, speaking, or breathing can happen within hours to weeks after an injection of XEOMIN if the muscles that you use to breathe and swallow become weak. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment with XEOMIN.
    • People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN.
    • Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN have the highest risk of getting these problems.
  • Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.

These symptoms can happen hours to weeks after you receive an injection of XEOMIN. These problems could make it unsafe for you to drive a car or do other dangerous activities.


Do not take XEOMIN if you: are allergic to XEOMIN or any of the ingredients in XEOMIN (see the end of this Guide for a list of ingredients in XEOMIN), had an allergic reaction to any other botulinum toxin product such as rimabotulinumtoxinB (Myobloc®), onabotulinumtoxinA (Botox®, Botox® Cosmetic), or abobotulinumtoxinA (Dysport®) or have a skin infection at the planned injection site.


Before receiving XEOMIN, tell your doctor about all of your medical conditions, including if you:

  • have a disease that affects your muscles and nerves (such as amyotrophic lateral sclerosis [ALS or Lou Gehrig's disease], myasthenia gravis or Lambert–Eaton syndrome)
  • have had any side effect from any other botulinum toxin in the past
  • have a breathing problem such as asthma or emphysema
  • have a history of swallowing problems or inhaling food or fluid into your lungs (aspiration)
  • have bleeding problems
  • have drooping eyelids
  • have plans to have surgery
  • have had surgery on your face
  • are pregnant or plan to become pregnant. It is not known if XEOMIN can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if XEOMIN passes into breast milk.

Tell your doctor about all of the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Talk to your doctor before you take any new medicines after you receive XEOMIN.


Using XEOMIN with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received XEOMIN in the past. Especially tell your doctor if you:

  • have received any other botulinum toxin product in the last four months
  • have received injections of botulinum toxin such as rimabotulinumtoxinB (MYOBLOC®), onabotulinumtoxinA (BOTOX®, BOTOX® COSMETIC) and abobotulinumtoxinA (DYSPORT®) in the past. Be sure your doctor knows exactly which product you received. The dose of XEOMIN may be different from other botulinum toxin products that you have received.
  • have recently received an antibiotic by injection
  • take muscle relaxants
  • take an allergy or cold medicine
  • take a sleep medicine

Ask your doctor if you are not sure if your medicine is one that is listed above.

Know the medicines you take. Keep a list of your medicines with you to show your doctor and pharmacist each time you get a new medicine.


Active Ingredients: botulinum toxin type A

Inactive Ingredients: human albumin and sucrose